In the healthcare industry, advanced Healthcare Packaging Testing methods are essential to ensure the reliability of sterile barrier systems under real-world conditions. Key tests include the Gelbo Flex Test, which evaluates a film’s resistance to pinhole formation during transportation, and assessments to mitigate Seal Creep Risk during ethylene oxide sterilization by analyzing adhesive coatings under elevated temperature and humidity. Other critical evaluations, such as puncture and abrasion resistance, ensure films can withstand sharp devices and repetitive stress. By prioritizing these application-specific tests, packaging engineers can optimize material selection, streamline development, and safeguard medical devices throughout their lifecycle.